Trump should be careful about going after The Freedom Caucus. That's 32 votes in The House. They could introduce a bill to impeach him and with the Democrats they would have 225 votes to impeach and 202 main-stream Republican votes against. (But who knows how many Trump-haters would go along with it?)

If he attacks them seriously, they could decide he is just damaging the Republican brand too much and go with Pence. Pence would be a much more reliable conservative choice and actually has some government experience.

Of course The Senate has to convict him with a 2/3 majority but if the case presented in The House was overwhelming they would seem like traitors if they didn't. This could be the beginning of the end for Trump.