If things do go downhill as rapidly as Phil suspects then 2018 will see the Senate flip, but I wouldn't count on seeing much in the way of third party victories then or...ever really.
The only goal of the third party needs to be the permanent destruction of a majority in EITHER of the TWO major parties, thus forcing BOTH parties to actually LEAD and do things which benefit the Middle Class.
The sheer brilliance of such a tactic might get through to enough voters IF enough oomph is put behind it.