WE NEED YOUR HELP!
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I hope HCQ works, I hope zinc works, I hope remdesivir works, I hope something else does.
But it hasn't been proven that any of these do work; it hasn't been proven that they don't, and it hasn't been proven if they may or may not help different degrees of patient severity; it hasn't been proven if they are good prophylactic drugs for SARS-CoV-2.
Look, about the in-vitro versus in-vivo: we don't need to go far. Remdesivir showed in-vitro activity against viruses of the Filoviridae family (Ebola). That generated the hypothesis that it might work against Ebola, in vivo. Well, so much for that. It was an utter failure in the real-life treatment of patients infected with Ebola. It's being repurposed now for COVID-19. We'll see.
Forty-five hundred dollars, for a ten dollar drug, if reports are any indicator.