Peak Prosperity "This Generation's Polio" 15 minutes into the video, they report on a multihospital retrospective study in which patients received HCN + Azithromycin with zinc or without zinc. A lot of the comparison factors did not show much difference. But these did:
..................Zinc.................No Zinc...........p
..................N=411................N=521
needed ICU........9.2%..................15.7%...........0.004
needed vent.......8.0%..................16.5%...........0.014
Expired/hospice..13.1%..................22.8%..........<0.0001
Exp/hos in ICU...73.6%..................74.4%...........0.934
Exp/hos sans ICU..6.9%..................13.2%...........0.004
This shows pretty conclusively that the combination of HCN + zinc makes a huge difference when you give it to patients not sick enough to need the ICU yet. It also shows that it has very little effect on patients that need the ICU.
===============================================================
At 25 minutes into the video, they also report on a paper on Ivermectin:
Administered once at 150 mcg/kg compared to patients with no Ivermectin. N=704 in each arm, matched for everything they could think of.
''''''''''''''''Ivermectin..........Control..........p
Dead with Vent.....7.3%...............21.3%
Overall Death......1.4%................8.5%.......<0.0001
They show the original paper URLs on the left, so you can go read the papers if that's your desire.
HCN+zinc and Ivermectine have totally different mechanisms, so it would probably be possible to use them together. Both are extremely cheap and widely available, especially in the Third World where one is a common anti-malarial and the other is an anti-parasite drug.
Well, but then, you have this:
https://ard.bmj.com/content/early/2020/05/07/annrheumdis-2020-217690For me, THAT's the nail in the coffin. If patients with lupus or RA who were already on HCQ are not faring any better when they catch COVID-19, so much for your theory that early use is beneficial.
Notably, 21.1% (121/573) of all reported patients with rheumatic disease in the registry were treated with an antimalarial prior to onset of COVID-19, yet 49.6% (60/121) required hospitalisation. In patients with SLE, frequency of hospitalisation with COVID-19 did not differ between individuals using an antimalarial versus non-users (55% (16/29) vs 57% (29/51), p=ns; χ2 test). In patients with lupus, escalation to maximum level of care (non-invasive ventilation, invasive ventilation or extracorporeal membrane oxygenation (ECMO)) was required regardless of HCQ use
As I suspected, HCQ is NOT effective for COVID-19, regardless of the phase of the illness. It is not prophylactic and it does not help even in early phases.
Maybe what is helping in your data is the zinc.
What, in your data, guarantees that HCQ is making any difference whatsoever? It's a combination treatment...
The paper I just posted indicates pretty CLEARLY that this medication doesn't help (which is consistent with what we're saying pretty much everywhere).
I suspect that the Columbia study will confirm it.
patients with lupus—even if they are using an antimalarial such as HCQ as baseline therapy—can develop SARS-CoV-2 infection and severe COVID-19 at similar frequency as lupus patients not on antimalarials.
And here is what I've been telling you forever, that in-vitro doesn't translate to in-vivo, automatically:
a putative role for HCQ in the treatment of COVID-19 has been suggested by its antiviral effect in cell culture systems. Given the assumptions made when moving from a cell-based model to a complex in vivo system, in vitro potency cannot be expected to translate into in vivo efficacy,
And in vivo HCQ doesn't seem to inhibit viral replication, either:
Notably, results from an open-label, randomised, controlled trial using doses as high as HCQ 1200mg for 3 days (followed by a maintenance dose of 800mg daily for 2–3 weeks) did not suggest efficacy of HCQ in suppressing viral replication.
My friend, I've been telling you... hydroxychloroquine just doesn't work for COVID-19, regardless of the phase of the illness. The overwhelming majority of data coming in more and more, indicates that it is a total fiasco.
This thing came from the most flawed "study" I've ever read in my professional life (which was never successfully replicated), by that idiot Professor Raoult in Marseille (who says that he doesn't believe in RCTs, LOL). Politicians jumped on it... but it doesn't work. Period, full stop.
Maybe ivermectin will help. Remdesivir certainly does modestly helps. HCQ? Nah.
