I actually think we are going to have a vaccine (or several) before the end of the year. Business will reopen where they planned for this and had enough reserves to hold out. A lot of them may move because they gave up leases, but then again there will be a lot of space available. There may be new businesses, as wealthy people invest. Remember, they have not gone broke at all during this pandemic: They just stopped making a lot of income.
What happens post vaccine when a pizza parlor opens? Huge business as people rush to get back to eating pizzas. What happens when sit-down restaurants open safely? Jam-packed. Yes, 20% of the population has endured unemployment, but a lot of people did not. I think the business environment is going to come roaring back.
Edit 5/28: Just got back from Home Depot at 2 PM. Parking lot was full. Turned around and came home.