I'm assuming Democratic control of the Senate and holding the House in 2022 would mean the filibuster is dead and the new voting rights act passed. That and the latest demographics shown in the census pretty much takes the Republican prospects out of the picture. Just the demographic changes alone were always going to kill the Republicans, unless they suddenly stop being such racist a-holes depending on voter suppression. If they did what their post-election-loss analyses said, and tried to recruit more people of color and Spanish speakers, they might hang in there for a while. Not decades, though.
I think Covid19 might change the outcomes in some purple races as well. Anti-maskers and anti-vaxxers seem to be heavily Republican for some reason, even though Trump started Operation Warpspeed AND got vaccinated! When a Trump voter dies, he usually stops voting Republican. Do they see the light when they almost die? We shall see.