Moderna vaccinations are holding up much better than Pfizer or J&J, in terms of antibody levels. That seems to affect your resistance to infection, though all are still effective against serious illness. If they are going to give boosters based on antibody levels, they should give them to folks who had J&J vaccines first.

Good news for the vaccine-hesitant: Molnupiravir is passing it's drug trial with 50% reduction of hospitalization, and 100% reduction of death. That's pretty good, and the cool thing is it looks like it will work against every RNA virus! You do need to take it as soon as symptoms appear, so no waiting until you need oxygen to survive. That's too late for an antiviral, because with Covid most of the virus is gone by then. But you just take a pill twice a day for five days, as opposed to an IV for monoclonal antibodies, so it's a lot easier to get sooner.

It works by making RNA replication fail by introducing junk nucleotides into the new strand, so it is messing with protein synthesis similar to mRNA vaccines, but it prevents immune system involvement instead of inducing it. On the con side, I suppose it could affect fertility if some of the drug leaked into the nucleus of dividing germ cells, That might make nonsense DNA in sperm or ova, that would be lethal mutations. It is a powerful mutagen, so it would make non-viable replicate DNA when it is at full strength. But I worry it could make cancer cells as it fades after treatment. We shall see. Also, it probably prevents you from getting any immunity if you take it when it works best. So 10 days later you are healed, but still vulnerable to reinfection immediately. The best treatment would be to get it AND a vaccination 10 days later. You can't do both at the same time, because it would do the same thing to the vaccine mRNA!

It works because we do no RNA replication: That's only done by RNA viruses. Cool idea, but it's long term effects are a bit scary.

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