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PAXLOVID is a new protease inhibitor from Pfizer that prevents SARS-COV2 replication with amazing results: The success rate depends on how early Covid infection treatment starts, but even five days after symptoms start it is over 90%! At three days after first symptoms it's over 98%. I thinks it's probably near 100% effective if given before any symptoms appear.
The mechanism is well understood: The virus make long proteins that have to be cut up into the functional proteins it needs. Protease enzymes do this precise cutting. This drug inhibits them. It does not interfere with DNA, Messenger RNA, or even vaccine mRNA. The only thing that uses these enzymes are RNA viruses, like corona viruses. But there is a reasonable chance the drug may work against other RNA viruses, like rabies, HIV, dengue, Ebola, zika, etc.
Protease inhibitors have been used for years for HIV-infected patients to keep them healthy.
