WE even got our share of villainization for using nukes and that was in response to Japan's continued attacks PLUS their plans to keep attacking others as well.
Unlike USA vs Japan, Ukraine did not declare war on Russia, so I would imagine that ANY use of nukes, even their so called "TACTICAL" ones (which carry larger yields than Fat Man and Little Boy) would result in pretty much EVERY nation on the planet cutting ties and trade with Russia, even the ones that need their oil and gas.
I think even China and Iran would take a step back and rethink.
Once Russia drops a nuke, there IS NO MORE reasoning with them, they are no longer a rational actor.