I think getting your Vitamin D levels up has been a pretty good prophylactic right from the beginning. MABs as theraputics have been around for a very long time, but they do tend to be extremely variant-specific. That's why the original "bam-bam" one from Regeneron was stopped soon after other variants appeared, and replaced by MAB "cocktails". They are generally a single (monoclonal) antibody against one specific part of the virus spike protein. There are three locations on the spike protein receptor binding site they can bind with, and Delta had changes in two of those. Omicron has changes in all three. That's why MABS tend to be much less effective as variants emerge. But if you get the right MAB for your variant, they work pretty well.

Still not as well as the mRNA vaccines. Keep in mind that we only have ONE sterilizing vaccine: HPV. Every other vaccine on Earth is not. They prevent serious illness and death, mostly. The fact that some SARS-COV2 vaccines do prevent almost all symptomatic disease before natural antibody contraction was just gravy. Nobody expected that. Remember, CDC said a 70% effective vaccine would be great. And that's 70% effective at preventing serious illness or death. Instead we got MUCH better vaccines by lucky accident. Antibody level contraction is exactly how the immune system works. It's not a "vaccine problem". It's a natural immune system function. Keeping high levels of circulating antibodies against everything you ever encounter would be lethal.

That's why we have memory T and B cells. Those are another layer of the immune system that remembers antigens, and quickly make new antibodies if they see it. Much quicker than the initial exposure. And they do that for years. People who recovered from SARS1 more than a decade ago still have memory T and B cells for it, and because of a natural evolution of antibody genes they respond to SARS-COV2 as well! The mRNA vaccines elicit a very good T and B cell response, and T cells use a much larger number of epitopes than antibodies, so they are much better at handling variants. Omicron infections in South Africa seem to be very mild, because most everybody already had Delta and their T-cells respond very well to Omicron. If you are triple-vaxxed, you get the same response.

I watched a YouTube video from Laura Walker the other day about making much broader MABs. They started with frozen serum sample from SARS1 patients, isolated antibodies, and ran the evolution in their lab. What they got was antibodies that work against SARS1, SARS-COV2, MERS, and any possible variant. And they are much much stronger than any of the current MABs. They are in clinical 2/3 trials right now. They also modified the antibody stem so it lasts about 6 months. Near the end of her talk, she also mentioned making vaccines against the invariant portion of these viruses that their antibody binds with. Those vaccines would work against every variant, and even against future corona virus spillovers.

I agree 100% with chunkstyle about labor shortages: It's an indictment against our economic system, because we are so far up conservative bungholes, employers can't understand that when people resist doing certain obnoxious jobs, you have to pay them more. That's a heretical concept after decades of wage stagnation. Long Beach port is jammed because no truck drivers? Nursing shortages? "Pay them more? Are you insane? If we pay nurses a living wage, we will have to raise our CEO compensation to a billion dollars a year!"