In the last two days, we have both Molnupiravir and Paxlovid approved with EUAs. Their use IS restricted, but fairly sensible. Instead of saying they are only to be used for very sick people (when they would be useless) the FDA has said they should be used for patients who are at high risk for serious disease or death. That would mean mostly the unvaxxed with comorbidities, but vaccinated elders with comorbidities should be able to get them too. They do have to be given as early as possible after exposure, preferably before the patient's oxygen saturation begins to drop. (But I doubt any anti-vaxxers will seek treatment soon enough for these drugs to be used.)

Interesting they approved them so close together. I've heard we could see resistance to antivirals within a few months. This why two or more drugs should be used together: If a virus develops resistance to one of the drugs, the other drug kills it. IE. if resistance develops in 1 out of thousand uses, then resistance to both should be 1 out of a million. Fortunately, these two drugs have completely different modes of operation, so they could be used together. Remdesivir actually has yet another mode, so all three could be used together if necessary. And Paxlovid will always be given with ritonavir, another antiviral drug.

But anybody getting them would be vaxxed as soon as they began treatment, so they would have some protection when the drugs stop. Otherwise they could get infected very quickly, like in days. Or maybe they could get an appropriate MAB, so they would have a few months of protection before needing vaccination.

Getting vaccinated and getting your Vitamin D level up is far far cheaper, and more effective a solution in the long run.


Educating anyone benefits everyone.