TWIV 860 on YouTube starts with a fundamental paper about recognition of "self RNA" versus "foreign RNA" (bacterial RNA, viral RNA, tRNA, and mitochondrial RNA) by proteins that are specifically in cells to recognize them. These proteins can pour out a cytokine that leads to cellular suicide (apoptosis), that is an important factor in the innate immune system. The authors theorized their results could lead to therapeutic RNA and mRNA vaccines. This paper was published in Immunity in 2005.

I bring it up as a historical point of interest: You need a lot of biochemistry to understand much of it, but I did learn some interesting things. Like the extant that RNA nucleotides are modified. Adenine, guanine, cytosine, & uracil are apparently the "high school version" of what is really going on! But I thought you might be interested because Katalin Karikó et al might just win a Nobel Prize for this.


Educating anyone benefits everyone.