PrEP is one thing and an HIV vaccine is another. Paxlovid is the corona virus version of PrEP. They both work by inhibiting their virus's protease, the viral enzyme that cuts the big mega-protein into the functional proteins. If that doesn't happen, the virus can't reproduce. Your immune system cleans up any remaining corona virions, until the infection is gone. But it can't do that with HIV. HIV is a retrovirus, which means it copies it's genome into some infected cells DNA. You can kill off all the "live" virus, and cells with that modified DNA will make new virus. This is why PrEP is a life sentence.

For a corona vaccine to work, it needs to make antibodies and sensitize T-cells that attack most of the virus. For an HIV vaccine to work, it has to "kill" every single HIV virus before it can do it's "retro trick". We don't know how to make vaccines that are perfect yet, and we don't know how to edit the HIV genes out of your DNA.

But there is another approach. People who's ancestors survived the Bubonic Plague may have a gene that denies entry for the Yersinia pestis bacteria into cells. This gene also renders single-gene people resistant to HIV and double-gene people HIV-proof. If we can figure out a way to get this gene into people (or maybe delete the "normal gene") then we might be able to end AIDS. The ironic thing is that HIV may just show us how to insert genes into cellular DNA, while it is "running".

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